Can I read T Cell Immunity to Oral Allergens on EtoBox?

T Cell Immunity to Oral Allergens by Thomas T MacDonald is a Immunology and Microbiology article available to read on EtoBox.

What is T Cell Immunity to Oral Allergens about?

Considerable light has been thrown on the mechanisms of oral tolerance (or, more correctly, orally-induced systemic tolerance) in the past 12-18 months. While it is very clear that T cell anergy and apoptosis can occur after being fed antigen, a major pathway that has been described in different models is the induction of regulatory T cells which secrete transforming growth factor beta. These cells have been designated Th3 cells but their relation to the in-vitro-generated Tr cells, which inhibit tissue-damaging T cell responses in the gut mucosa, is not known. An important discovery is that food antigens have major systemic effects on T cells, similar in many ways to those seen following intravenous injection of soluble antigens. This conceptually moves us away from the notion that there is something special about mucosal (compared to systemic) lymphoid tissue to the notion that it is the type of antigens seen in the gut (i.e. digested, soluble polypeptides) which dictates the types of response seen there. After initial excitement, clinical trials using oral tolerance to treat autoimmune disease have been somewhat disappointing.

Who reads T Cell Immunity to Oral Allergens?

Author

Thomas T MacDonald

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0952-7915)

Published

1999

Language

EN

Field

Immunology and Microbiology (Life Sciences)