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Atrial Natriuretic Peptide in Children with Pneumonia by Michal Haviv; Eitan Haver; David Lichtstein; Haggit Hurvitz; Aharon Klar is a Medicine article available to read on EtoBox.

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## Abstract Atrial natriuretic peptide (ANP) has known natriuretic, diuretic, and vasodilatatory effects. It is synthesized and stored in the atrial cells. Stretching of the atrial muscle fibers during an increase in venous return sets a response of ANP release into the blood stream. High levels of ANP were measured in a number of lung diseases. Pneumonia in children is frequently accompanied by the hyponatremia of the syndrome of inappropriate antidiuretic hormone (ADH) secretion (SIADH). High levels of ANP were found among patients with SIADH. Our objective was to determine if ANP plasma levels are altered in children with pneumonia, and to evaluate a possible correlation between severity of pneumonia and ANP levels. Blood samples from 28 children diagnosed with pneumonia were collected. Plasma ANP levels were determined by radioimmunoassay and compared to levels in 25 children without pneumonia. ANP levels in the pneumonia group (mean ± SD, 16.02 ± 11.69 pg/ml) increased significantly (__P__ < 0.01) compared to levels in the control group (mean ± SD, 7.44 ± 9.29 pg/ml). Children in the pneumonia group also exhibited low levels of plasma sodium (mean ± SD, 134.88 ± 2.5 mmol/l) co

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Author
Michal Haviv; Eitan Haver; David Lichtstein; Haggit Hurvitz; Aharon Klar
Publisher
John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)
Published
2005
Language
EN
Field
Medicine (Health Sciences)

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