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Protein-coated microplastics corona complex: An underestimated risk of microplastics by Hongwei Luo; Qingping Du; Zuanjia Zhong; Yanbin Xu; Jinping Peng is a Environmental Science article available to read on EtoBox.

What is Protein-coated microplastics corona complex: An underestimated risk of microplastics about?

Traditionally, toxicity of microplastics is ascribed to the chemicals adsorbed on them. However, microplastics can also interact with biomolecules, such as secretory proteins from aquatic organisms, and form protein-coated microplastics corona complex with unknown toxic effects. Here, we investigated the toxic effects of polystyrene microplastics (PS) and bovine serum albumin (BSA) coated PS corona complex (PS + BSA) on adult zebrafish (Danio rerio) intestines. The food intake ratio, accumulation and distribution of microplastics, histopathological changes, and molecular effects related to the antioxidant system in the intestine were studied. For the first time, we observed that PS + BSA aggregated on the inner surface of the zebrafish intestine, whereas PS dispersed. The aggregation of PS + BSA resulted in increased microplastics accumulation and longer residence time in the zebrafish intestine, which inhibited food intake and generated reactive oxygen species (ROS) in the intestine. Furthermore, the functions of the Keap1-Nrf2-ARE antioxidant signaling pathway and the activation of antioxidant enzymes were significantly affected by PS + BSA after a 21-day exposure. Ultimately, a

Who reads Protein-coated microplastics corona complex: An underestimated risk of microplastics?

Author

Hongwei Luo; Qingping Du; Zuanjia Zhong; Yanbin Xu; Jinping Peng

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Environmental Science (Physical Sciences)