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Can I read Prognostic Factors and Treatment Impact on Overall Survival in Adult Craniopharyngioma on EtoBox?
Prognostic Factors and Treatment Impact on Overall Survival in Adult Craniopharyngioma by Matthew Awad; John T. Butterfield; Sanjay Dhawan; Matthew A. Tyler; Andrew S. Venteicher is a Medicine article available to read on EtoBox.
What is Prognostic Factors and Treatment Impact on Overall Survival in Adult Craniopharyngioma about?
Objective To examine the demographics, tumor characteristics, treatments, and clinical outcomes of a large adult craniopharyngioma population. Methods The 2004–2018 National Cancer Database was queried to investigate adult patients with craniopharyngioma. Univariable and multivariable Cox hazard ratio analysis was conducted to analyze the overall survival (OS) impact of demographic and clinical variables. Results A total of 666 adult patients with craniopharyngioma were identified with a mean age of 51 years (standard deviation 16 years). On multivariable analysis, independent of demographic and clinical variables, increased age, uninsured status, Medicaid, Medicare, Charlson–Deyo Comorbidity Index of 2, and tumor size greater than 40 mm were independently associated with worse OS. There was no significant difference in survival between histologic subtypes. Gross total resection (GTR) (hazard ratio [HR] 0.602, 95% confidence interval [CI] 0.384–0.942, P = 0.026) and subtotal resection (STR) with adjuvant radiotherapy (HR 0.316, 95% CI 0.140–0.710, P = 0.005) were independently associated with improved OS. GTR with radiotherapy trended towards improved OS (HR 0.601, 95% CI 0.334–1.0
Who reads Prognostic Factors and Treatment Impact on Overall Survival in Adult Craniopharyngioma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Matthew Awad; John T. Butterfield; Sanjay Dhawan; Matthew A. Tyler; Andrew S. Venteicher
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)