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Research Progress on Drugs for Diabetes Based on Insulin Receptor/insulin Receptor Substrate by Jingqian Su; Lu Tang; Yingsheng Luo; Jingran Xu; Songying Ouyang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Research Progress on Drugs for Diabetes Based on Insulin Receptor/insulin Receptor Substrate about?

The number of people with diabetes worldwide is increasing annually, resulting in a serious economic burden. Insulin resistance is a major pathology in the early onset of diabetes mellitus, and therefore, related drug studies have attracted research attention. The insulin receptor/insulin receptor substrate (INSR/IRS) serves as the primary conduit in the insulin signal transduction cascade, and dysregulation of this pathway can lead to insulin resistance. Currently, there exist a plethora of hypoglycemic drugs in the market; however, drugs that specifically target INSR/IRS are comparatively limited. The literature was collected by direct access to the PubMed database, and was searched using the terms "diabetes mellitus; insulin resistance; insulin receptor; insulin receptor substrate; diabetes drug" as the main keywords for literature over the last decade. This article provides a comprehensive analysis of the structure and function of INSR and IRS proteins, as well as the drugs used for the treatment of diabetes. Additionally, it serves as a valuable reference for the advancement of novel therapeutic agents for diabetes management.

Who reads Research Progress on Drugs for Diabetes Based on Insulin Receptor/insulin Receptor Substrate?

Author

Jingqian Su; Lu Tang; Yingsheng Luo; Jingran Xu; Songying Ouyang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)