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Eponemycin Analogues: Syntheses and Use as Probes of Angiogenesis by Ny Sin; Lihao Meng; Hak Auth; Craig M. Crews is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Eponemycin Analogues: Syntheses and Use as Probes of Angiogenesis about?

AbstractÐDerivatives of the epoxy-b-aminoketone containing natural product eponemycin have been prepared in order to study the molecular mode of action of this anti-angiogenic compound. Synthesis and use of a biotinylated dihydroeponemycin analogue demonstrated that dihydroeponemycin forms a covalent adduct with at least two intracellular proteins in human endothelial cells. Pretreatment of cells with a ®ve equivalent excess of dihydroeponemycin precluded biotin-dihydroeponemycin binding indicating a speci®c interaction between natural product and the target proteins. This biotin-dihydroeponemycin derivative will prove useful in the puri®cation and identi®cation of eponemycin receptors.

Who reads Eponemycin Analogues: Syntheses and Use as Probes of Angiogenesis?

Author

Ny Sin; Lihao Meng; Hak Auth; Craig M. Crews

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)