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Accounts in Drug Discovery: Case Studies in Medicinal Chemistry (RSC Drug Discovery Series, Volume 4) by Joel C. Barrish, Percy H. Carter, Peter T. W. Cheng, Robert Zahler is a nonfiction available to read on EtoBox.

What is Accounts in Drug Discovery: Case Studies in Medicinal Chemistry (RSC Drug Discovery Series, Volume 4) about?

Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" and "next generation" compounds that aim to improve upon first generation agents. This volume surveys the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology, including proof of concept in the clinic for novel biological targets. The case studies include medicinal chemistry stories on recently approved and marketed drugs, but also chronicle "near-misses", i.e., exemplary compounds that may have proceeded well into the clinic but for various reasons did not result in a successful registration. As the vast majority of projects fail prior to registration, much can be learned from such narratives. By sharing a wide range

Who reads Accounts in Drug Discovery: Case Studies in Medicinal Chemistry (RSC Drug Discovery Series, Volume 4)?

Author

Joel C. Barrish, Percy H. Carter, Peter T. W. Cheng, Robert Zahler

Publisher

Royal Society of Chemistry

Published

2011

Language

EN

ISBN

9781849731980

Category

nonfiction

Subjects

Science, Chemistry, Medical