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Can I read Anti-inflammatory withanolides from the aerial parts of Physalis minima on EtoBox?
Anti-inflammatory withanolides from the aerial parts of Physalis minima by Wenhui Liu; Han Zhang; Hongxu Wan; Jiantong Hou; Dongho Lee; Jing Xu; Yuanqiang Guo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Anti-inflammatory withanolides from the aerial parts of Physalis minima about?
Eight undescribed and two known withanolides were obtained from the aerial parts of Physalis minima. The structures of these compounds were defined by spectroscopic methods including 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) data analysis. Physminin E was elucidated to be a rare 13,14-seco-withanolide. Inhibitory effects of these compounds on nitric oxide (NO) production were evaluated by using LPS-activated RAW264.7 macrophages, and physminin C was shown to be the most active with an IC value of 3.5 μM. The further mechanistic analysis of NO inhibition was performed by molecular docking and Western blotting.
Who reads Anti-inflammatory withanolides from the aerial parts of Physalis minima?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Wenhui Liu; Han Zhang; Hongxu Wan; Jiantong Hou; Dongho Lee; Jing Xu; Yuanqiang Guo
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)