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This study reports the synthesis and in vitro evaluation of novel acyl carbamates and acyl/diacyl ureas for their efficacy against the protozoan parasites Toxoplasma gondii and Cryptosporidium parvum. Five compounds were identified with low micromolar activity against these parasites and demonstrated selectivity in human cells, particularly compound JS-1-09, which showed a significant selectivity index. The findings suggest potential for these compounds in developing new anti-protozoal drugs to address the

Author

Trọng Nguyễn Doãn

Language

EN