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Diffusion Barriers Evoked in the Rat Cortex by Reactive Astrogliosis by Tamara Roitbak; Eva Syková is a Neuroscience article available to read on EtoBox.
What is Diffusion Barriers Evoked in the Rat Cortex by Reactive Astrogliosis about?
Changes in extracellular space (ECS) diffusion parameters in astrogliotic tissue around a unilateral cortical stab wound were determined from concentrationtime profiles of tetramethylammonium (TMA ϩ ) using TMA ϩ -selective microelectrodes. Three diffusion parameters-ECS volume fraction ␣ (␣ ϭ ECS volume/ total tissue volume), tortuosity ( 2 ϭ D/ADC; where D is the free and ADC is the apparent diffusion coefficient of TMA ϩ in the brain), and nonspecific TMA ϩ uptake kЈ-were determined at 3, 7, 21, and 35 days postwounding (dpw), in the hemispheres ipsilateral and contralateral to the lesion. Following diffusion experiments, tissue sections were immunostained for glial fibrillary acidic protein (GFAP) and chondroitin-sulphate proteoglycans (CSPG). In the area 300-1000 μm around the wound, ␣ was increased at 3, 7, and 21 dpw by about 20% but returned to control values at 35 dpw; was increased at all four intervals, reaching a maximum at 7 dpw. kЈ was lower than in the contralateral hemisphere at 7, 21, and 35 dpw. Measurements 1,500-2,000 μm from the wound revealed only an increase in at 7 dpw. The time course of changes in ECS diffusion parameters closely correlated with increased
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It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Tamara Roitbak; Eva Syková
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 1999
- Language
- EN
- Field
- Neuroscience (Life Sciences)