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Indications for Whole-Brain Radiation Therapy by Michael Huo; Fabio Ynoe de Moraes; Matthew Foote; Mark B. Pinkham; Gustavo N. Marta; John H. Suh is a book available to read on EtoBox.

What is Indications for Whole-Brain Radiation Therapy about?

A 52-year-old Caucasian man presents with increasing fatigue, cough, weight loss, headaches, nausea, ataxia, and right arm weakness. His comorbidities include chronic obstructive pulmonary disease, hypertension, and hypercholesterolemia. He is a current smoker with a 60 pack-year history. CT of the chest/abdomen/ pelvis reveals a 5 cm left upper lobe mass, enlarged mediastinal adenopathy, and a 3 cm left adrenal mass. CT of the head reveals 16 enhancing brain lesions ranging in size from 4 mm to 18 mm with no hydrocephalus and minimal midline shift, with mild-to-moderate associated vasogenic edema. MRI brain (Fig. 12.1) reveals the aforementioned intracranial disease on CT, plus an additional nine lesions measuring up to 4 mm. He is admitted to hospital and commenced on dexamethasone 8 mg daily with symptomatic improvement. A subsequent CT-guided biopsy of the lung mass reveals lung adenocarcinoma, TTF-1 positive. No ALK or EGFR mutations are detected, and PDL1 expression is less than 1%. He is referred to radiation oncology for further management of his brain metastases. Given the number and size of brain metastases, he is deemed unsuitable for neurosurgical resection and radiosur

Author

Michael Huo; Fabio Ynoe de Moraes; Matthew Foote; Mark B. Pinkham; Gustavo N. Marta; John H. Suh

Publisher

Springer International Publishing

Published

2020

Language

EN

ISBN

9783030437398

Subjects

Medical, Medicine