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Preseasonal Local Allergoid Immunotherapy to Grass Pollen in Children: a Double‐blind, Placebo‐controlled, Randomized Trial by C. Caffarelli; L. G. Sensi; F. Marcucci; G. Cavagni is a Medicine article available to read on EtoBox.
What is Preseasonal Local Allergoid Immunotherapy to Grass Pollen in Children: a Double‐blind, Placebo‐controlled, Randomized Trial about?
**Background:** We assessed the efficacy of preseasonal local allergoid immunotherapy in a group of children with asthma and/or rhinitis and/or rhinoconjunctivitis due to grass pollen. **Methods:** We randomly assigned 24 children allergic to grass pollen to receivelocal allergoid immunotherapy for 3 months before the pollen season and 24 such patients to receive identically appearing placebo. The immunotherapy consisted of tablets of monomeric allergoid grass pollen allergens held in the mouth until they dissolved and then swallowed. The study was double‐blind. Symptoms and medications were scored on diary cards during the pollen season. Nasal eosinophil cationic protein levels were measured by the monoclonal antibodies EG1 and EG2 outside the pollen season and at low and at high pollen concentration during the pollen season. **Results:** The active‐treatment group had a statistically significant reduction of total symptoms (__P__<0.05), especially bronchial symptoms (__P__<0.05), in comparison with the placebo group. Immunotherapy was well tolerated and compliance was good. Nasal levels of EG2 and EG1 increased significantly during the pollen season, but there was no difference b
Who reads Preseasonal Local Allergoid Immunotherapy to Grass Pollen in Children: a Double‐blind, Placebo‐controlled, Randomized Trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- C. Caffarelli; L. G. Sensi; F. Marcucci; G. Cavagni
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-4538)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)