About this Neuroscience article

Electrical Stimulation of Isolated Retina with Microwire Glass Electrodes by Lee Johnson; F.Keith Perkins; Thomas O’Hearn; Perry Skeath; Charles Merritt; Joseph Frieble; Srinivas Sadda; Mark Humayun; Dean Scribner is a Neuroscience article available to read on EtoBox.

The development of high-resolution retinal prostheses fabricated from silicon wafers presents an interesting problem: how to electrically bridge the space between the flat silicon wafer and the curved retinal surface. One potential "bridge" is a microwire glass electrode. In this paper we present our results in evaluating microwire glass electrodes. We stimulated isolated rabbit retina (n = 5) with a 0.0256 cm 2 microwire electrode. The current and pulse duration were varied from 498 to 1660 A and 0.1 to 3 ms, respectively. We found that short pulses produced more spikes per coulomb and longer pulses produced more spikes per milliamp. The optimal pulse duration range of 0.7-1 ms was identified as a compromise between the advantages of short and long pulses. Stimulation of isolated rabbit retina with microwire glass results in consistent neuronal spike formation at safe charge density, 20.7 ± 4.3 C/cm 2 . We also examined the response of retinas (n = 6) to stimulation with a smaller microwire electrode, 0.0002 cm 2 . We found that less current was required (15 A versus 756 A) for a 1 ms pulse, but at the expense of greater charge density (75 C/cm 2 versus 29.5 C/cm 2 ). Nonetheless,

Author

Lee Johnson; F.Keith Perkins; Thomas O’Hearn; Perry Skeath; Charles Merritt; Joseph Frieble; Srinivas Sadda; Mark Humayun; Dean Scribner

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-0270)

Published

2004

Language

EN

Field

Neuroscience (Life Sciences)