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Relationship of ^99m^technetium labelled macroaggregated albumin (^99m^Tc-MAA) uptake by colorectal liver metastases to response following Selective Internal Radiation Therapy (SIRT) by Dhabuwala, Atul ;Lamerton, Prue ;Stubbs, Richard S is a scholarly article available to read on EtoBox.

What is Relationship of ^99m^technetium labelled macroaggregated albumin (^99m^Tc-MAA) uptake by colorectal liver metastases to response following Selective Internal Radiation Therapy (SIRT) about?

## Background SIRT is an emerging treatment for liver tumours which relies on the selective uptake by tumour of ^90^Y microspheres following hepatic arterial injection. Response rates of around 90% are reported. Hepatic arterial injection of MAA gives an indication of the expected distribution of ^90^Y microspheres within the liver. This study sought to determine if the MAA scan could be predictive of subsequent tumour response. ## Methods 58 patients with colorectal hepatic metastases received SIRT. All had pre-treatment MAA planar images and CT scans which were retrospectively reviewed. Tumours were qualitatively considered "cold", "equivocal" or "hot" based on MAA uptake and the ratio of uptake in tumour and normal liver tissue was calculated (TNR). Following SIRT (which included the administration of hepatic arterial Angiotensin 2) tumour response was assessed by CEA changes one to two months after treatment and by serial CT. ## Results Uptake was classified as "hot" in 37 patients (Group 1) and "equivocal" or "cold" in 21 (Group 2). CEA levels fell dramatically in over 90% of patients. The falls were not significantly different between the groups. There was no correlation betw

Author

Dhabuwala, Atul ;Lamerton, Prue ;Stubbs, Richard S

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central; Springer Science and Business Media LLC (ISSN 1471-2385)

Published

2005

Language

EN