Can I read Siderophore-Mediated microbial iron(III) uptake: An exercise in chiral recognition on EtoBox?

Siderophore-Mediated microbial iron(III) uptake: An exercise in chiral recognition by Dr. A. Shanzer; J. Libman; P. Yakirevitch; Y. Hadar; Y. Chen; E. Jurkevitch is a Chemistry article available to read on EtoBox.

What is Siderophore-Mediated microbial iron(III) uptake: An exercise in chiral recognition about?

## Abstract Molecular recognition by microbial receptors for siderophores [natural iron(III) carriers] is examined with synthetic iron(III) carriers as structural probes. The iron(III) carriers have been designed to reproduce the two essential features of the natural siderophores: the capability to form octahedral iron(III) binding cavities and to fit specific membrane receptors. Specifically, analogs of tripodal ferrichrome and linear ferrioxamines have been prepared and examined. The ferrichrome analogs rely on C~3~‐symmetric binders that are assembled from triscarboxylates as anchors, amino acids as bridges, and terminal hydroxamate groups as binding sites. The ferrioxamine analogs are based on linear assemblies of three identical monomers, each derived from a chiral amino acid. The deliberate use of animo acid residues as variable building blocks enables us to systematically modify the molecules' envelopes and the preferred absolute configuration of the iron(III) complexes until optimal performance is reached. Examination of the synthetic analogs in __Pseudomonas putida__ demonstrates that the domains around the iron(III) center and their chiral sense dictate the extent of reco

Who reads Siderophore-Mediated microbial iron(III) uptake: An exercise in chiral recognition?

Author

Dr. A. Shanzer; J. Libman; P. Yakirevitch; Y. Hadar; Y. Chen; E. Jurkevitch

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-0042)

Published

1993

Language

EN

Field

Chemistry (Physical Sciences)