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Normalized Blood Flow Index in Optical Coherence Tomography Angiography Provides a Sensitive Biomarker of Early Diabetic Retinopathy by Albert K. Dadzie; David Le; Mansour Abtahi; Behrouz Ebrahimi; Taeyoon Son; Jennifer I. Lim; Xincheng Yao is a Medicine article available to read on EtoBox.

What is Normalized Blood Flow Index in Optical Coherence Tomography Angiography Provides a Sensitive Biomarker of Early Diabetic Retinopathy about?

## Purpose To evaluate the sensitivity of normalized blood flow index (NBFI) for detecting early diabetic retinopathy (DR). ## Methods Optical coherence tomography angiography (OCTA) images of healthy controls, diabetic patients without DR (NoDR), and patients with mild nonproliferative DR (NPDR) were analyzed in this study. The OCTA images were centered on the fovea and covered a 6 mm × 6 mm area. Enface projections of the superficial vascular plexus (SVP) and the deep capillary plexus (DCP) were obtained for the quantitative OCTA feature analysis. Three quantitative OCTA features were examined: blood vessel density (BVD), blood flow flux (BFF), and NBFI. Each feature was calculated from both the SVP and DCP and their sensitivities to distinguish the three cohorts of the study were evaluated. ## Results The only quantitative feature capable of distinguishing all three cohorts was NBFI in the DCP image. Comparative study revealed that both BVD and BFF were able to distinguish the controls and NoDR from mild NPDR. However, neither BVD nor BFF was sensitive enough to separate NoDR from the healthy controls. ## Conclusions The NBFI has been demonstrated as a sensitive biomarker of ear

Who reads Normalized Blood Flow Index in Optical Coherence Tomography Angiography Provides a Sensitive Biomarker of Early Diabetic Retinopathy?

Author

Albert K. Dadzie; David Le; Mansour Abtahi; Behrouz Ebrahimi; Taeyoon Son; Jennifer I. Lim; Xincheng Yao

Publisher

The Association for Research in Vision and Ophthalmology

Published

2023

Language

EN

Field

Medicine (Health Sciences)