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Use of Isotopically Labelled Octanoic Acid to Assess the Effect of Meal Size on Gastric Emptying by Sarah J. Jackson; Leslie J. C. Bluck; W. Andrew Coward is a Chemistry article available to read on EtoBox.

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## Abstract It has been proposed that the ^13^C‐octanoic acid breath test (OBT) provides a safe, non‐radioactive means of measuring gastric emptying. However, deuterated octanoic acid provides a better marker when compared with scintigraphy, as the kinetics are less complex than those of the ^13^C label. The appearance of ^2^H in saliva is modelled as a two‐compartment body water system, using an asymmetric triangular gastric emptying function. This study compared the ^2^H‐octanoic acid saliva test (OST) with the OBT in measuring altered states of gastric emptying in the nutritional context of diet manipulation. Gastric emptying was measured using the OST and OBT in a three‐way crossover study involving 12 healthy male and female subjects (mean BMI = 23.4 kg/m^2^, aged 24–57 years). Following an overnight fast, subjects were given an egg meal, labelled with 10 μL/kg body weight ^2^H‐octanoic acid and 100 μL ^13^C‐octanoic acid. The meal was nutritionally manipulated to provide a 1 MJ, 2 MJ or 3 MJ meal. Breath and saliva samples were collected at regular intervals for 6 h, with further saliva samples being collected over four subsequent days. ^2^H isotopic enrichment in saliva and

Who reads Use of Isotopically Labelled Octanoic Acid to Assess the Effect of Meal Size on Gastric Emptying?

Author

Sarah J. Jackson; Leslie J. C. Bluck; W. Andrew Coward

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-4198)

Published

2004

Language

EN

Field

Chemistry (Physical Sciences)