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Knockdown of Long Noncoding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis by Targeting miR-124 in Retinoblastoma by Shujun Liu; Guigang Yan; Junfu Zhang; Lianzhi Yu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Knockdown of Long Noncoding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis by Targeting miR-124 in Retinoblastoma about?

Evidence suggests that the long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in cancer tissues, and its elevated expression is associated with hyperproliferation. However, the underlying mechanisms regarding the role of MALAT1 in retinoblastoma (RB) remain unclear. This study aimed to explore the functional role of MALAT1 in RB by targeting miR-124. The results showed that the expression of MALAT1 was significantly higher in the Y79 cell line than in the ARPE-19 cell line (__p__ < 0.01). Moreover, MALAT1 silence inhibited cell viability, migration, and invasion and promoted apoptosis in Y79 cells (__p__ < 0.05, __p__ < 0.01, or __p__ < 0.001). miR-124 was upregulated by MALAT1 silence and hence was identified as a target of MALAT1 (__p__ < 0.05 or __p__ < 0.001). In addition, miR-124 suppression inhibited cell apoptosis and remarkably abolished the inhibitory effects of MALAT1 silence on cell viability, migration, and invasion (__p__ < 0.05, __p__ < 0.01, or __p__ < 0.001). In addition, Slug was a target of miR-124 and regulated cell viability, migration, invasion, and apoptosis in Y79 cells (__p__ < 0.05, __p__ < 0.01, or __

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Author

Shujun Liu; Guigang Yan; Junfu Zhang; Lianzhi Yu

Publisher

Computers, Materials and Continua (Tech Science Press)

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)