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Can I read Local and Systemic Increase in Lipid Peroxidation After Moderate Experimental Traumatic Brain Injury on EtoBox?
Local and Systemic Increase in Lipid Peroxidation After Moderate Experimental Traumatic Brain Injury by Domenico Praticò; Peter Reiss; Lina X. Tang; Syan Sung; Joshua Rokach; Tracy K. McIntosh is a Neuroscience article available to read on EtoBox.
What is Local and Systemic Increase in Lipid Peroxidation After Moderate Experimental Traumatic Brain Injury about?
Traumatic brain injury is a common event associated with neurological dysfunction. Oxidative damage, may contribute to some of these pathologic changes. We used a specific and sensitive marker of lipid peroxidation, the isoprostane 8,12-iso-iPF(2alpha) -VI, to investigate whether local and also systemic lipid peroxidation were induced following lateral fluid percussion (FP) brain injury in the rat. Animals were anesthetized and subjected to lateral FP brain injury of moderate severity, or to sham injury as controls. Urine was collected before anesthesia (baseline), 6 and 24 h after injury. Blood was collected at baseline, 1, 6 and 24 h after injury. Animals were killed 24 h after surgery and their brains removed for biochemical analysis. No significant difference was observed at baseline (preinjury) for urine and plasma 8,12-iso-iPF(2alpha) -VI levels between injured and sham-operated animals. By contrast, plasma and urinary levels increased significantly already at 1 and further increased 24 h following brain injury, when compared to sham-operated animals. Finally, compared with sham, injured animals had a significant increase in brain 8,12-iso-iPF(2alpha) -VI levels. These result
Who reads Local and Systemic Increase in Lipid Peroxidation After Moderate Experimental Traumatic Brain Injury?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Domenico Praticò; Peter Reiss; Lina X. Tang; Syan Sung; Joshua Rokach; Tracy K. McIntosh
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2002
- Language
- EN
- Field
- Neuroscience (Life Sciences)