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High-dose paclitaxel and its combination with CSF1R inhibitor in polymeric micelles for chemoimmunotherapy of triple negative breast cancer by Chaemin Lim; Duhyeong Hwang; Mostafa Yazdimamaghani; Hannah Marie Atkins; Hyesun Hyun; Yuseon Shin; Jacob D. Ramsey; Patrick D. Rädler; Kevin R. Mott; Charles M. Perou; Marina Sokolsky-Papkov; Alexander V. Kabanov is a Materials Science article available to read on EtoBox.
What is High-dose paclitaxel and its combination with CSF1R inhibitor in polymeric micelles for chemoimmunotherapy of triple negative breast cancer about?
The presence of immunosuppressive immune cells in tumors is a significant barrier to the generation of therapeutic immune responses. Similarly, in vivo triple-negative breast cancer (TNBC) models often contain prevalent, immunosuppressive tumor-associated macrophages in the tumor microenvironment (TME), resulting in breast cancer initiation, invasion, and metastasis. Here, we test systemic chemoimmunotherapy using small-molecule agents, paclitaxel (PTX), and colony-stimulating factor 1 receptor (CSF1R) inhibitor, PLX3397, to enhance the adaptive T cell immunity against TNBCs in immunocompetent mouse TNBC models. We use high-capacity poly(2-oxazoline) (POx)-based polymeric micelles to greatly improve the solubility of insoluble PTX and PLX3397 and widen the therapeutic index of such drugs. The results demonstrate that high-dose PTX in POx, even as a single agent, exerts strong effects on TME and induces longterm immune memory. In addition, we demonstrate that the PTX and PLX3397 combination provides consistent therapeutic improvement across several TNBC models, resulting from the repolarization of the immunosuppressive TME and enhanced T cell immune response that suppress both the p
Who reads High-dose paclitaxel and its combination with CSF1R inhibitor in polymeric micelles for chemoimmunotherapy of triple negative breast cancer?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Chaemin Lim; Duhyeong Hwang; Mostafa Yazdimamaghani; Hannah Marie Atkins; Hyesun Hyun; Yuseon Shin; Jacob D. Ramsey; Patrick D. Rädler; Kevin R. Mott; Charles M. Perou; Marina Sokolsky-Papkov; Alexander V. Kabanov
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)