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Can I read Non-steroidal Anti-inflammatory Drugs Induce Immunogenic Cell Death in Suppressing Colorectal Tumorigenesis on EtoBox?
Non-steroidal Anti-inflammatory Drugs Induce Immunogenic Cell Death in Suppressing Colorectal Tumorigenesis by Rochelle Fletcher; Jingshan Tong; Denise Risnik; Brian J. Leibowitz; Yi-Jun Wang; Fernando Concha-Benavente; Jonathan M. DeLiberty; Donna B. Stolz; Reet K. Pai; Robert L. Ferris; Robert E. Schoen; Jian Yu; Lin Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Non-steroidal Anti-inflammatory Drugs Induce Immunogenic Cell Death in Suppressing Colorectal Tumorigenesis about?
Use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with reduced risk of colorectal cancer (CRC). However, the mechanism by which NSAIDs suppress colorectal tumorigenesis remains unclear. We previously showed that NSAIDs selectively kill emerging tumor cells via death receptor (DR) signaling and a synthetic lethal interaction mediated by the proapoptotic Bcl-2 family protein BID. In this study, we found NSAIDs induce endoplasmic reticulum (ER) stress to activate DR signaling and BID in tumor suppression. Importantly, our results unveiled an ER stress-and BID-dependent immunogenic effect of NSAIDs, which may be critical for tumor suppression. NSAID treatment induced hallmarks of immunogenic cell death (ICD) in CRC cells and colonic epithelial cells upon loss of APC tumor suppressor, and elevated tumor-infiltrating lymphocytes (TILs) in the polyps of APC Min/+ mice. ER stress inhibition or BID deletion abrogated the antitumor and immunogenic effects of NSAIDs. Furthermore, increased ER stress and TILs were detected in human advanced adenomas from NSAID-treated patients. Together, our results suggest that NSAIDs induce ER stress-and BIDmediated ICD to restore immunosur
Who reads Non-steroidal Anti-inflammatory Drugs Induce Immunogenic Cell Death in Suppressing Colorectal Tumorigenesis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Rochelle Fletcher; Jingshan Tong; Denise Risnik; Brian J. Leibowitz; Yi-Jun Wang; Fernando Concha-Benavente; Jonathan M. DeLiberty; Donna B. Stolz; Reet K. Pai; Robert L. Ferris; Robert E. Schoen; Jian Yu; Lin Zhang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)