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Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma by Hung-Chen Chen; Yung-Che Chen; Tsu-Nai Wang; Wen-Feng Fang; Ya-Chun Chang; Yu-Mu Chen; I-Ya Chen; Meng-Chih Lin; Ming-Yu Yang is a Medicine article available to read on EtoBox.

What is Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma about?

## Purpose Circadian clock is synchronized to the 24-hour day by the daily light–dark cycle and proper function of circadian rhythm is essential for many physiological processes. Disruption of circadian rhythm can affect disease processes and influence disease severity, treatment responses, and even survivorship. In this retrospective case-controlled study, we tried to explore whether expression of circadian clock genes was disturbed in patients with bronchial asthma. ## Patients and Methods We performed real-time quantitative reverse transcriptase-polymerase chain reactions to examine the expression of the nine core circadian clock genes (__BMAL1__, __CK1ε__, __CLOCK__, __CRY1__, __CRY2__, __PER1__, __PER2__, __PER3__, and __TIM__) in total leukocytes of peripheral blood collected at chest clinics from 120 patients with asthma and 60 health individuals. ## Results Expression levels of the nine circadian clock genes were significantly different between patients and healthy individuals, but not associated with the asthma control status. We also noted the difference of __PER3__ expression in asthmatic patients with and without nocturnal symptoms. In well-controlled asthmatics, expres

Who reads Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma?

Author

Hung-Chen Chen; Yung-Che Chen; Tsu-Nai Wang; Wen-Feng Fang; Ya-Chun Chang; Yu-Mu Chen; I-Ya Chen; Meng-Chih Lin; Ming-Yu Yang

Publisher

Dove

Published

2021

Language

EN

Field

Medicine (Health Sciences)