Can I read Excellent Survival Outcomes of Pediatric Patients With Acute Myeloid Leukemia Treated With the MASPORE 2006 Protocol on EtoBox?

Excellent Survival Outcomes of Pediatric Patients With Acute Myeloid Leukemia Treated With the MASPORE 2006 Protocol by Natalia Sutiman; Mya Soe Nwe; Eunice En Ni Lai; Denyse Kawai Lee; Mei Yoke Chan; Allen Eng-Juh Yeoh; Shui Yen Soh; Wing Leung; Ah Moy Tan is a Medicine article available to read on EtoBox.

What is Excellent Survival Outcomes of Pediatric Patients With Acute Myeloid Leukemia Treated With the MASPORE 2006 Protocol about?

## Purpose: To determine the prognostic factors in pediatric patients with acute myeloid leukemia (aml) and to assess whether their outcomes have improved over time. ## Patients and methods: Sixty-two patients with aml excluding acute promyelocytic leukemia were retrospectively analyzed. patients in the earlier cohort (n = 36) were treated on the medical research council (mrc) aml12 protocol, whereas those in the recent cohort (n = 26) were treated on the malaysia-singapore aml protocol (maspore 2006), which differed in terms of risk group stratification, cumulative anthracycline dose, and timing of hematopoietic stem-cell transplantation for high-risk patients. ## Results: Significant improvements in 10-year overall survival and event-free survival were observed in patients treated with the recent maspore 2006 protocol compared to the earlier mrc aml12 protocol (overall survival: 88.0% ± 6.5% vs 50.1% ± 8.6%, p = .002; event-free survival: 72.1% ± 9.0 vs 50.1% ± 8.6%, p = .045). in univariate analysis, patients in the recent cohort had significantly lower intensive care unit admission rate (11.5% vs 47.2%, p = .005) and numerically lower relapse rate (26.9% vs 50.0%, p = .068) com

Who reads Excellent Survival Outcomes of Pediatric Patients With Acute Myeloid Leukemia Treated With the MASPORE 2006 Protocol?

Author

Natalia Sutiman; Mya Soe Nwe; Eunice En Ni Lai; Denyse Kawai Lee; Mei Yoke Chan; Allen Eng-Juh Yeoh; Shui Yen Soh; Wing Leung; Ah Moy Tan

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)