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Using the Canine Microbiome to Bridge Translation of Cancer Immunotherapy from Pre-clinical Murine Models to Human Clinical Trials by Kara T. Kleber; Khurshid R. Iranpur; Lauren M. Perry; Sylvia M. Cruz; Aryana M. Razmara; William T. N. Culp; Michael S. Kent; Jonathan A. Eisen; Robert B. Rebhun; Robert J. Canter is a Immunology and Microbiology article available to read on EtoBox.

What is Using the Canine Microbiome to Bridge Translation of Cancer Immunotherapy from Pre-clinical Murine Models to Human Clinical Trials about?

The microbiome has clearly been established as a cutting-edge field in tumor immunology and immunotherapy. Growing evidence supports the role of the microbiome in immune surveillance, self-tolerance, and response to immune checkpoint inhibitors such as anti PD-L1 and CTLA-4 blockade (1–6). Moreover, recent studies including those using fecal microbial transplantation (FMT) have demonstrated that response to checkpoint immunotherapies may be conferred or eliminated through gut microbiome modulation (7, 8). Consequently, studies evaluating microbiota-host immune and metabolic interactions remain an area of high impact research. While observations in murine models have highlighted the importance of the microbiome in response to therapy, we lack sufficient understanding of the exact mechanisms underlying these interactions. Furthermore, mouse and human gut microbiome composition may be too dissimilar for discovery of all relevant gut microbial biomarkers. Multiple cancers in dogs, including lymphoma, high grade gliomas, melanomas and osteosarcoma (OSA) closely resemble their human analogues, particularly in regard to metastasis, disease recurrence and response to treatment. Importantly

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Author

Kara T. Kleber; Khurshid R. Iranpur; Lauren M. Perry; Sylvia M. Cruz; Aryana M. Razmara; William T. N. Culp; Michael S. Kent; Jonathan A. Eisen; Robert B. Rebhun; Robert J. Canter

Published

2022

Language

EN

Field

Immunology and Microbiology (Life Sciences)