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Epstein‐Barr virus‐associated gastric carcinoma in southern India: A comparison with a large‐scale Japanese series by Jayasree Kattoor; Chihaya Koriyama; Suminori Akiba; Tetsuhiko Itoh; Shan Ding; Yoshito Eizuru; Elizabeth K. Abraham; B. Chandralekha; N.S. Amma; M. Krishnan Nair is a scholarly article available to read on EtoBox.

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## Abstract Epidemiological and clinicopathological features of Epstein‐Barr virus (EBV) associated gastric carcinoma was compared in India and Japan, two countries differing markedly in gastric cancer incidence. Using in situ hybridization assay, the presence of EBV‐encoded small RNA (EBER) was examined in 215, and 2,011 gastric cancer cases in Kerala, India, and Japan, respectively. Ten cases (5%), all males, in the Indian series were EBER‐positive. This frequency was similar to that in the Japanese series (6.2%). As was the case with Japanese series, the EBV‐associated gastric carcinoma in the Indian series was observed most frequently in the middle part of the stomach (1 in antrum, 4 in middle part, 2 in cardia, and 3 unknown), and, histologically, the diffuse type Lauren's classification (8 cases) was more common than the intestinal type (2 cases). Virus subtyping by PCR‐RFLP revealed that all of the 10 EBV strains isolated from the EBER‐positive Indian cases were subtype A, and wild‐type F for Bam HI F region. In Bam HI I region, 8 cases were type C and the remaining 2 cases were type D. In either series, there was no significant difference in the frequency of tumors with p53

Author

Jayasree Kattoor; Chihaya Koriyama; Suminori Akiba; Tetsuhiko Itoh; Shan Ding; Yoshito Eizuru; Elizabeth K. Abraham; B. Chandralekha; N.S. Amma; M. Krishnan Nair

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

2002

Language

EN