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Can I read Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology on EtoBox?
Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology by Dennis van der Meer; Alexey A. Shadrin; Kevin O’Connell; Francesco Bettella; Srdjan Djurovic; Thomas Wolfers; Dag Alnæs; Ingrid Agartz; Olav B. Smeland; Ingrid Melle; Jennifer Monereo Sánchez; David E.J. Linden; Anders M. Dale; Lars T. Westlye; Ole A. Andreassen; Oleksandr Frei; Tobias Kaufmann is a Neuroscience article available to read on EtoBox.
What is Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology about?
BACKGROUND: Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite low genetic correlations. Through the use of analytical methods that allow for mixed directions of effects, this overlap may be leveraged to improve our understanding of underlying mechanisms of schizophrenia and enrich polygenic risk prediction outcome. METHODS: We ran a multivariate genome-wide analysis of 175 brain morphology measures using data from 33,735 participants of the UK Biobank and analyzed the results in a conditional false discovery rate together with schizophrenia genome-wide association study summary statistics of the Psychiatric Genomics Consortium (PGC) Wave 3. We subsequently created a pleiotropy-enriched polygenic score based on the loci identified through the conditional false discovery rate approach and used this to predict schizophrenia in a nonoverlapping sample of 743 individuals with schizophrenia and 1074 healthy controls. RESULTS: We found that 20% of the loci and 50% of the genes significantly associated with schizophrenia were also ass
Who reads Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dennis van der Meer; Alexey A. Shadrin; Kevin O’Connell; Francesco Bettella; Srdjan Djurovic; Thomas Wolfers; Dag Alnæs; Ingrid Agartz; Olav B. Smeland; Ingrid Melle; Jennifer Monereo Sánchez; David E.J. Linden; Anders M. Dale; Lars T. Westlye; Ole A. Andreassen; Oleksandr Frei; Tobias Kaufmann
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)