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Bomapin Is a Redox-sensitive Nuclear Serpin That Affects Responsiveness of Myeloid Progenitor Cells to Growth Environment by Patrycja Przygodzka; Björn Ramstedt; Tobias Tengel; Göran Larsson; Malgorzata Wilczynska is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Bomapin Is a Redox-sensitive Nuclear Serpin That Affects Responsiveness of Myeloid Progenitor Cells to Growth Environment about?
## Abstract ## Background Haematopoiesis is a process of formation of mature blood cells from hematopoietic progenitors in bone marrow. Haematopoietic progenitors are stimulated by growth factors and cytokines to proliferate and differentiate, and they die via apoptosis when these factors are depleted. An aberrant response to growth environment may lead to haematological disorders. Bomapin (serpinb10) is a hematopoietic- and myeloid leukaemia-specific protease inhibitor with unknown function. ## Results We found that the majority of naturally expressed bomapin was located in the nucleus. Both the natural and recombinant bomapin had a disulfide bond which linked the only two bomapin cysteines: one located in the CD-loop and the other near the C-terminus. Computer modelling showed that the cysteines are distant in the reduced bomapin, but can easily be disulfide-linked without distortion of the overall bomapin structure. Low-level ectopic expression of bomapin in bomapin-deficient K562 cells resulted in about 90% increased cell proliferation under normal growth conditions. On the other hand, antisense-downregulation of natural bomapin in U937 cells resulted in a decreased cell prolif
Who reads Bomapin Is a Redox-sensitive Nuclear Serpin That Affects Responsiveness of Myeloid Progenitor Cells to Growth Environment?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Patrycja Przygodzka; Björn Ramstedt; Tobias Tengel; Göran Larsson; Malgorzata Wilczynska
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2000]-2018.; Springer Science and Business Media LLC (ISSN 1471-2121)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)