Can I read Oncogenic Gene Fusions in Cancer: from Biology to Therapy on EtoBox?

Oncogenic Gene Fusions in Cancer: from Biology to Therapy by Stephen V. Liu & Misako Nagasaka & Judith Atz & Flavio Solca & Leonhard Müllauer is a book available to read on EtoBox.

What is Oncogenic Gene Fusions in Cancer: from Biology to Therapy about?

Signal Transduction and Targeted Therapy, doi:10.1038/s41392-025-02161-7Oncogenic gene fusions occur across a broad range of cancers and are a defining feature of some cancer types. Cancers driven bygene fusion products tend to respond well to targeted therapies, where available; thus, detection of potentially targetableoncogenic fusions is necessary to select optimal treatment. Detection methods include non-sequencing methods, such asfluorescence in situ hybridization and immunohistochemistry, and sequencing methods, such as DNA- and RNA-based nextgeneration sequencing (NGS). While NGS is an efficient way to analyze multiple genes of interest at once, economic and technicalfactors may preclude its use in routine care globally, despite several guideline recommendations. The aim of this review is topresent a summary of oncogenic gene fusions, with a focus on fusions that affect tyrosine kinase signaling, and to highlight theimportance of testing for oncogenic fusions. We present an overview of the identification of oncogenic gene fusions and therapiesapproved for the treatment of cancers harboring gene fusions, and summarize data regarding treating fusion-positive cancers withno cu

Author

Stephen V. Liu & Misako Nagasaka & Judith Atz & Flavio Solca & Leonhard Müllauer

Publisher

x

Published

2025

Language

EN