Opening book details…
Can I read Dahuang Zhechong Pill suppresses colorectal cancer liver metastasis via ameliorating exosomal CCL2 primed pre-metastatic niche on EtoBox?
Dahuang Zhechong Pill suppresses colorectal cancer liver metastasis via ameliorating exosomal CCL2 primed pre-metastatic niche by Chen, Chunhui; Yao, Xueqing; Xu, Yihua; Zhang, Qingyuan; Wang, Hao; Zhao, Liang; Wen, Ge; Liu, Yawei; Jing, Linlin; Sun, Xuegang is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Dahuang Zhechong Pill suppresses colorectal cancer liver metastasis via ameliorating exosomal CCL2 primed pre-metastatic niche about?
## Ethnopharmacological relevance: Dahuang zhechong pill (dzp) is a classical formula from "synopsis of prescriptions of the golden chamber". it has been used for treatment of abdominal masses (including tumorous diseases) for thousands of years. ## Aim of the study: Our previous work showed that dzp suppresses ccl-4 induced hepatic fibrosis by downregulating the expression of interleukin-13. we aimed to test if dzp suppresses the metastasis of colorectal cancer (crc) by ameliorating the fibrosis status of the future metastatic organ. ## Materials and methods: Liver metastasis was observed by injection of mc38-egfp cells with stably expressing enhanced green fuorescence protein beneath the splenic capsule of c57bl/6j mice. mc38-egfp-derived exosomes were analyzed by label-free comparative proteomics. mrna expression was determined by quantitative pcr. protein expression was determined by immunohistochemistry, immunofuorescence and western blot. collagen deposition was determined by masson staining. all data were statistically analyzed using spss. ## Results: Dzp drastically reduced the metastatic tumor number and fluorescence intensity in a splenic liver metastasis model. it also l
Who reads Dahuang Zhechong Pill suppresses colorectal cancer liver metastasis via ameliorating exosomal CCL2 primed pre-metastatic niche?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Chen, Chunhui; Yao, Xueqing; Xu, Yihua; Zhang, Qingyuan; Wang, Hao; Zhao, Liang; Wen, Ge; Liu, Yawei; Jing, Linlin; Sun, Xuegang
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-8741)
- Published
- 2019
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)