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Redefining CT perfusion‐based ischemic core estimates for the ghost core in early time window stroke by Manisha Koneru; Meisam Hoseinyazdi; Dhairya A. Lakhani; Cynthia Greene; Karen Copeland; Richard Wang; Risheng Xu; Licia Luna; Justin M. Caplan; Adam A. Dmytriw; Adrien Guenego; Jeremy J. Heit; Gregory W. Albers; Max Wintermark; Luis F. Gonzalez; Victor C. Urrutia; Judy Huang; Kambiz Nael; Richard Leigh; Elisabeth B. Marsh; Argye E. Hillis; Rafael H. Llinas; Vivek S. Yedavalli is a Medicine article available to read on EtoBox.

What is Redefining CT perfusion‐based ischemic core estimates for the ghost core in early time window stroke about?

## Abstract ## Background and Purpose In large vessel occlusion (LVO) stroke patients, relative cerebral blood flow (rCBF)<30% volume thresholds are commonly used in treatment decisions. In the early time window, nearly infarcted but salvageable tissue volumes may lead to pretreatment overestimates of infarct volume, and thus potentially exclude patients who may otherwise benefit from intervention. Our multisite analysis aims to explore the strength of relationships between widely used pretreatment CT parameters and clinical outcomes for early window stroke patients. ## Methods Patients from two sites in a prospective registry were analyzed. Patients with LVOs, presenting within 3 hours of last known well, and who were successfully reperfused were included. Primary short‐term neurological outcome was percent National Institutes of Health Stroke Scale (NIHSS) change from admission to discharge. Secondary long‐term outcome was 90‐day modified Rankin score. Spearman's correlations were performed. Significance was attributed to __p__‐value⩽.05. ## Results Among 73 patients, median age was 66 (interquartile range 54‐76) years. Among all pretreatment imaging parameters, rCBF<30%, rCBF<34

Who reads Redefining CT perfusion‐based ischemic core estimates for the ghost core in early time window stroke?

Author

Manisha Koneru; Meisam Hoseinyazdi; Dhairya A. Lakhani; Cynthia Greene; Karen Copeland; Richard Wang; Risheng Xu; Licia Luna; Justin M. Caplan; Adam A. Dmytriw; Adrien Guenego; Jeremy J. Heit; Gregory W. Albers; Max Wintermark; Luis F. Gonzalez; Victor C. Urrutia; Judy Huang; Kambiz Nael; Richard Leigh; Elisabeth B. Marsh; Argye E. Hillis; Rafael H. Llinas; Vivek S. Yedavalli

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)