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Can I read Microglial Reaction and Neuronal Death in the Hippocampus of Rat Models of Epilepsy on EtoBox?
Microglial Reaction and Neuronal Death in the Hippocampus of Rat Models of Epilepsy by Ikuo Tooyama; Tsutomu Nishimura; Eiji Nakagawa; Hiroyuki Morita; Shuji Uemura; Yoshinari Aimi; Osamu Yasuhara; Hiroshi Kimura is a Medicine article available to read on EtoBox.
What is Microglial Reaction and Neuronal Death in the Hippocampus of Rat Models of Epilepsy about?
Reaction of microglial cells as well as DNA fragmentation in pyramidal cells was investigated using immunohisto‐chemistry and __in situ__ end‐labeling method (TUNEL) in the hippocampus of rats after rapid kindling or kainic acid treatment. In intact rats, no or very little DNA fragmentation was detected in the hippocampus. Resting microglia distributed evenly throughout the hippocampus. Neither major histocompatibility complex antigens class I (MHC I) nor class II (MHC II) immunoreactivity was seen in the hippocampus. In the rapid‐kindling model, no DNA fragmentation, reactive microglia or MHC antigen‐positive cells were present in the hippocampus. In rats given an intraperitoneal injection of kainic acid (12 mg/kg), reactive microglial cells were seen around pyramidal neurons in the CA1 and CA3 field of the hippocampus as well as in the hilus of the dentate gyrus at 3 h. At that point in time, DNA fragmentation was not detected. DNA fragmentation was clearly observed, mainly in the CA1 region of the hippocampus, from 24 h to 4 weeks after the kainic acid injection. The number of reactive microglia was quickly increased and reached a maximum at 7 days after the injection, and conti
Who reads Microglial Reaction and Neuronal Death in the Hippocampus of Rat Models of Epilepsy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ikuo Tooyama; Tsutomu Nishimura; Eiji Nakagawa; Hiroyuki Morita; Shuji Uemura; Yoshinari Aimi; Osamu Yasuhara; Hiroshi Kimura
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0919-6544)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)