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Correlation between CSF and blood neurofilament light chain protein: a systematic review and meta-analysis by Alagaratnam, Jasmini (author);von Widekind, Sophia (author);De Francesco, Davide (author);Underwood, Jonathan (author);Edison, Paul (author);Winston, Alan (author);Zetterberg, Henrik (author);Fidler, Sarah (author) is a Medicine article available to read on EtoBox.

What is Correlation between CSF and blood neurofilament light chain protein: a systematic review and meta-analysis about?

## Objective To assess the overall pooled correlation coefficient estimate between cerebrospinal fluid (CSF) and blood neurofilament light (NfL) protein. ## Methods We searched Medline, Embase and Web of Science for published articles, from their inception to 9 July 2019, according to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Studies reporting the correlation between CSF and blood NfL in humans were included. We conducted a random-effects meta-analysis to calculate the overall pooled correlation coefficient estimate, accounting for correlation technique and assay used. Heterogeneity was assessed using the I^2^ statistic test. In sensitivity analyses, we calculated the pooled correlation coefficient estimate according to blood NfL assay: single-molecule array digital immunoassay (Simoa), electrochemiluminescence (ECL) assay or ELISA. ## Results Data were extracted from 36 articles, including 3961 paired CSF and blood NfL samples. Overall, 26/36 studies measured blood NfL using Simoa, 8/36 ECL, 1/36 ELISA and 1 study reported all three assay results. The overall meta-analysis demonstrated that the pooled correlation coefficient estimate for CSF an

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Author
Alagaratnam, Jasmini (author);von Widekind, Sophia (author);De Francesco, Davide (author);Underwood, Jonathan (author);Edison, Paul (author);Winston, Alan (author);Zetterberg, Henrik (author);Fidler, Sarah (author)
Publisher
BMJ
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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