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Evaluation of the wound healing potentials of two subspecies of Hypericum perforatum on cultured NIH3T3 fibroblasts by Miriş Dikmen; Yusuf Öztürk; Gianni Sagratini; Massimo Ricciutelli; Sauro Vittori; Filippo Maggi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract For centuries, __Hypericum perforatum__ has been used in folk medicine to treat wounds. In the present study, the wound healing activities of extracts of __H. perforatum__ ssp. __perforatum__ (HPP) and __H. perforatum__ ssp. __veronense__ (HPV) were evaluated by comparing with a titrated extract of __Centella asiatica__ (TECA) on NIH3T3 fibroblasts. The cells were incubated with the extracts. Using microscopical methods by staining cells, mitotic ability, morphological changes and collagen production in the fibroblasts were evaluated as parameters to approach possible wound repair mechanism(s). The wound healing activity caused an increase in the percentage of polygonal fibroblasts and in collagen granule numbers in fibroblasts of HPP and HPV. At 1 μg/mL, HPP caused a greater increase in mitotic cell numbers than HPV. The most increases in polygonal cell numbers were observed with HPV at 1 and 10 μg/mL. The number of collagen granules was increased with 1 μg/mL HPV being higher than HPP. As an indication of cytotoxic effects, round cells in response to HPV and HPP extracts, were found to be increased in concentrations higher than 10–50 μg/mL. The results indicated that
Who reads Evaluation of the wound healing potentials of two subspecies of Hypericum perforatum on cultured NIH3T3 fibroblasts?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Miriş Dikmen; Yusuf Öztürk; Gianni Sagratini; Massimo Ricciutelli; Sauro Vittori; Filippo Maggi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)