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Asymmetric cyclization reactions. Cyclization of substituted 4-pentenals into cyclopentanone derivatives by rhodium(I) with chiral ligands by Yukari Taura; Masakazu Tanaka; Xiao-Ming Wu; Kazuhisa Funakoshi; Kiyoshi Sakai is a Chemistry article available to read on EtoBox.

What is Asymmetric cyclization reactions. Cyclization of substituted 4-pentenals into cyclopentanone derivatives by rhodium(I) with chiral ligands about?

## Abstracl: Asymmetnc cycltsation of substituted 4-pentenals (1a.b.c: IIa,b.c,d) by Rh(l) wtth chtral ligands was tested, ad substrate (IId) with a btdkier substittuttt at C4 undetwent more siereoselective cyclization by Rh(I)-((+)-DIPMC) to yuld sttbstrtuted cyclopentatwne (IIId) The Rh(I) with (+)-DIPUC was found to proceed in a werent manner porn the Wilkinson-catalyzed cyclizalion Stereoselective cyclization is one of the indispensable reactions for the synthesis of natural products, and there are several excellent methods for the cyclization. Among them, it is well known that metal-catalyzed cyclization plays an essential role in the synthesis of structurally complex organic molecules. l Rh(I)-catalyzed cyclization of Cpentenals into cyclopentanones was fist found by our laboratory?a Further studies evolved this reaction using the Wilkinson complex into the stereocontrolled cyclization of 3,4\_disubstituted 4-pentenals to cis-3,4disubstituted cyclopentanones,2b and this method has been widely applied to the synthesis of several natural products.3

Who reads Asymmetric cyclization reactions. Cyclization of substituted 4-pentenals into cyclopentanone derivatives by rhodium(I) with chiral ligands?

Author

Yukari Taura; Masakazu Tanaka; Xiao-Ming Wu; Kazuhisa Funakoshi; Kiyoshi Sakai

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

1991

Language

EN

Field

Chemistry (Physical Sciences)