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Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5 by Catherine Moermans; Chloé Brion; Grégory Bock; Sophie Graff; Sara Gerday; Haleh Nekoee; Christophe Poulet; Noémie Bricmont; Monique Henket; Virginie Paulus; Françoise Guissard; Renaud Louis; Florence Schleich is a Medicine article available to read on EtoBox.
What is Sputum Type 2 Markers Could Predict Remission in Severe Asthma Treated With Anti-IL-5 about?
Background Biotherapies targeting IL-5 allow a tangible improvement of asthma. However, all patients do not respond the same way to these treatments. Even if high blood eosinophil counts seem to be associated with a reduction in exacerbations with treatment targeting IL-5, we lack biomarkers for the prediction of remission after these very expensive treatments. Research Question Does the sputum of patients with severe eosinophilic asthma show biomarkers of remission after therapy targeting IL-5? Study Design and Methods This observational study included 52 patients with severe asthma initiated with anti-IL-5 therapy and recruited from the asthma clinic of the CHU of Liege, Belgium. Remission was defined as patients who combined the following at 1 year after therapy: no chronic treatment with oral corticosteroids; no exacerbation; asthma control questionnaire score 19, or both; FEV1 of ≥ 80% predicted, improvement of FEV1 of ≥ 10%, or both; and a blood eosinophil count < 300 cells/μL. Eosinophil peroxidase (EPX), IgE, IL-3, IL-4, IL-5, IL-13, IL-25, IL-33, granulocyte-macrophage colony-stimulating factor, thymic stromal lymphopoietin (TSLP), and eotaxin-1 levels were measured in t
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- Author
- Catherine Moermans; Chloé Brion; Grégory Bock; Sophie Graff; Sara Gerday; Haleh Nekoee; Christophe Poulet; Noémie Bricmont; Monique Henket; Virginie Paulus; Françoise Guissard; Renaud Louis; Florence Schleich
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)