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Pharmacotherapy of Inflammatory Bowel Diseases by prof. MUDr. Milan Lukáš CSc is a scholarly article available to read on EtoBox.

What is Pharmacotherapy of Inflammatory Bowel Diseases about?

Aminosalicylates, corticosteroids, immunosuppressants, and recently also biological therapy are the mainstays of pharmacotherapy of inflammatory bowel diseases (IBD). Aminosalicylates (sulphasalazine, mesalazine) are essential drugs for both aggressive and maintenance treatment of patients with ulcerative colitis. They are administered orally, in limited disease they may also be administered locally in the form of suppository or rectal enema. Corticosteroids with systemic effect have a strong anti-inflammatory effect and are used in oral or parenteral therapy in patients with a severe course of intestinal inflammations. The treatment with corticosteroids is burdened with a risk of serious adverse effects the intensity of which increases with the dose and duration of administration. Corticosteroids are of no importance in preventing the relapse of IBD. An alternative of the treatment of ileocaecal Crohn's disease with a mild to moderate inflammatory activity are topical steroids (budesonide) administered orally. Immunosuppressants, particularly thiopurines, are indicated in the treatment of chronically active forms of IBD, in the case of some extraintestinal manifestations, and in t

Author

prof. MUDr. Milan Lukáš CSc

Published

2009