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Comparison of the Effects of Venlafaxine, Desipramine, and Paroxetine on Noradrenaline‐ and Methoxamine‐evoked Constriction of the Dorsal Hand Vein by Abdelmawla; Langley; Szabadi; Bradshaw is a Medicine article available to read on EtoBox.

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__Aims__ To examine whether the antidepressant venlafaxine, a novel serotonin‐noradrenaline re‐uptake inhibitor (SNRI), can modify α‐adrenoceptor‐mediated venoconstriction in man. The effects of venlafaxine were compared with those of desipramine, a tricyclic antidepressant with noradrenaline uptake inhibiting properties, and paroxetine, a selective serotonin re‐uptake inhibitor (SSRI), on noradrenaline‐and methoxamine‐evoked venoconstriction using the dorsal hand vein compliance technique. __Methods Fifteen healthy male volunteers participated in five weekly experimental sessions. Each session was associated with a clinically effective dose of an antidepressant or placebo. The following oral dosages were used: venlafaxine 75 mg, venlafaxine 150 mg, desipramine 100 mg, paroxetine 20 mg, or placebo. A double‐blind, cross‐over, balanced design was used. In each session, dose–response curves to both locally infused noradrenaline acid tartrate (0.1–33.33 ng min^−1^ ) and methoxamine hydrochloride (0.5–121.5 μg min^−1^__ ) were constructed. Systolic and diastolic blood pressure and pulse rate were measured in the supine and erect positions. Salivation was measured by the dental roll tec

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Author

Abdelmawla; Langley; Szabadi; Bradshaw

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

1999

Language

EN

Field

Medicine (Health Sciences)