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In Vivo Efficacy of Photodynamic Therapy in Three New Xenograft Models of Human Retinoblastoma by Isabelle Aerts; Pascal Leuraud; Jocelyne Blais; Anne-lise Pouliquen; Philippe Maillard; Claude Houdayer; Jérôme Couturier; Xavier Sastre-Garau; David Grierson; François Doz; Marie France Poupon is a Medicine article available to read on EtoBox.
What is In Vivo Efficacy of Photodynamic Therapy in Three New Xenograft Models of Human Retinoblastoma about?
## Purpose: Retinoblastoma is the most common primary intraocular tumor in children. in industrialized countries, 95% of patients are cured by chemotherapy and conservative treatments. however, these treatments can increase the risk of secondary tumors in patients with a constitutional alteration of the rb1 gene. photodynamic therapy represents a nonmutagenic therapeutic approach, and may reduce the incidence of secondary tumors. to study the in vivo efficacy of photodynamic therapy, human retinoblastoma xenografts were established in nude mice. ## Methods: Three xenografted cell lines, rb102-fer, rb109-lak and rb111-mil, were characterized and used for therapeutic evaluation. mice were randomly divided into control and treatment groups with 5-8 mice in each group. treatment groups received irradiation alone, photosensitizer alone or both in 2 of the 3 models and in the third model, photosensitizer plus irradiation was compared to untreated controls. mthpc was injected intraperitoneally at a dose of 0.6mg/kg and verteporfin intravenously at a dose of 1mg/kg. illuminations were performed 24h after mthpc and 1h after verteporfin injections. ## Results: A transient but significant res
Who reads In Vivo Efficacy of Photodynamic Therapy in Three New Xenograft Models of Human Retinoblastoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Isabelle Aerts; Pascal Leuraud; Jocelyne Blais; Anne-lise Pouliquen; Philippe Maillard; Claude Houdayer; Jérôme Couturier; Xavier Sastre-Garau; David Grierson; François Doz; Marie France Poupon
- Publisher
- Elsevier BV
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)