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Biosynthetic Pathways of Aminoglycosides and Their Engineering by Je Won Park; Yeon Hee Ban; Sang-Jip Nam; Sun-Shin Cha; Yeo Joon Yoon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Biosynthetic Pathways of Aminoglycosides and Their Engineering about?

Despite decades long clinical usage, aminoglycosides still remain a valuable pharmaceutical source for fighting Gram-negative bacterial pathogens, and their newly identified bioactivities are also renewing interest in this old class of antibiotics. As Nature’s gift, some aminoglycosides possess natural defensive structural elements that can circumvent drug resistance mechanisms. Thus, a detailed understanding of aminoglycoside biosynthesis will enable us to apply Nature’s biosynthetic strategy towards expanding structural diversity in order to produce novel and more robust aminoglycoside analogs. The engineered biosynthesis of novel aminoglycosides is required not only to develop effective therapeutics against the emerging ‘superbugs’ but also to reinvigorate antibiotic lead discovery in readiness for the emerging post-antibiotic era.

Who reads Biosynthetic Pathways of Aminoglycosides and Their Engineering?

Author

Je Won Park; Yeon Hee Ban; Sang-Jip Nam; Sun-Shin Cha; Yeo Joon Yoon

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)