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Creatine Levels in Patients with Phenylketonuria and Mild Hyperphenylalaninemia: A Pilot Study by Elvira Verduci; Maria Teresa Carbone; Laura Fiori; Claudia Gualdi; Giuseppe Banderali; Claudia Carducci; Vincenzo Leuzzi; Giacomo Biasucci; Gian Vincenzo Zuccotti is a Medicine article available to read on EtoBox.
What is Creatine Levels in Patients with Phenylketonuria and Mild Hyperphenylalaninemia: A Pilot Study about?
Background: Creatine (Cr) levels are strongly dependent on diets, including animal-derived proteins. Cr is an important metabolite as it represents a source of stored energy to support physical performance and potentially sustain positive effects such as improving memory or intelligence. This study was planned to assess Cr levels in PKU children adhering to a diet low in phenylalanine (Phe) content and compared with those of children with mild hyperphenylalaninemia (MHP) on a free diet. Methods: This retrospective pilot study analyzed Cr levels from Guthrie cards in 25 PKU and 35 MHP subjects. Anthropomorphic and nutritional data of the study populations were assessed, compared and correlated. Results: Cr levels of PKU subjects were significantly lower than those of MHP subjects and correlated to the low intake of animal proteins. Although no deficiencies in PKU subjects were identified, PKU subjects were found to have a 26-fold higher risk of displaying Cr levels <25° percentile than MHP counterparts. Conclusions: This pilot study suggests that Cr levels might be concerningly low in PKU children adhering to a low-Phe diet. Confirmatory studies are needed in PKU patients of differe
Who reads Creatine Levels in Patients with Phenylketonuria and Mild Hyperphenylalaninemia: A Pilot Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Elvira Verduci; Maria Teresa Carbone; Laura Fiori; Claudia Gualdi; Giuseppe Banderali; Claudia Carducci; Vincenzo Leuzzi; Giacomo Biasucci; Gian Vincenzo Zuccotti
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)