Can I read Telomere Dysfunction in Nonalcoholic Fatty Liver Disease and Cryptogenic Cirrhosis on EtoBox?

Telomere Dysfunction in Nonalcoholic Fatty Liver Disease and Cryptogenic Cirrhosis by Ido Laish; Batya Mannasse-Green; Ruth Hadary; Tal Biron-Shental; Fred M. Konikoff; Aliza Amiel; Yona Kitay-Cohen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Telomere Dysfunction in Nonalcoholic Fatty Liver Disease and Cryptogenic Cirrhosis about?

Nonalcoholic fatty liver disease (NAFLD) and cryptogenic cirrhosis (CC) are considered preneoplastic conditions that might progress to hepatocellular carcinoma. We evaluated parameters of telomere dysfunction in these patient groups to study the correlation between telomere length and the progression of NAFLD. We analyzed peripheral lymphocytes from 22 patients with NAFLD, 20 patients with CC, and 20 healthy, age-matched controls. Telomere length was analyzed using quantitative fluorescence in situ hybridization, and cellular senescence was evaluated by the percentage of cells with senescence-associated heterochromatin foci. The expression of telomerase reverse transcriptase (hTERT) mRNA was measured using polymerase chain reaction, and telomere capture (TC) was assessed with 2 Cytocell probes, 15qter and 13qter. Shorter telomere length and increased cellular senescence was demonstrated in patients with NAFLD, compared to the CC patients and healthy controls. While hTERT mRNA was significantly decreased, TC was increased in CC patients, compared to the NAFLD group and healthy individuals. Thus, there is a correlation between hTERT mRNA expression and telomere length in patients wit

Who reads Telomere Dysfunction in Nonalcoholic Fatty Liver Disease and Cryptogenic Cirrhosis?

Author

Ido Laish; Batya Mannasse-Green; Ruth Hadary; Tal Biron-Shental; Fred M. Konikoff; Aliza Amiel; Yona Kitay-Cohen

Published

2016

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)