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Electroacupuncture Ameliorates Intestinal Barrier Destruction in Mice With Bile Duct Ligation–Induced Liver Injury by Activating the Cholinergic Anti-Inflammatory Pathway by Wei Lei; Changcheng Zhao; Jiasen Sun; Yanling Jin; Zhijun Duan is a Medicine article available to read on EtoBox.

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## Objectives: Electroacupuncture (ea) at zusanli (st36) can attenuate inflammation in different rodent models. however, the therapeutic mechanisms underlying its action in inhibiting intestinal barrier destruction and liver injury in cholestasis mice have not been clarified. this study aimed at investigating whether ea at st36 could activate the cholinergic anti-inflammatory pathway to inhibit intestinal barrier destruction and liver injury in cholestasis mice. ## Materials and methods: Male hmox1 c57bl/6 mice were randomized and subjected to a sham or bile duct ligation (bdl) surgery. the bdl mice were randomized and treated with, or without (bdl group), sham ea at st36 (bdl+sham-st36) or ea at st36 (bdl+st36), or received α-bungarotoxin (α-bgt), a specific inhibitor of nicotinic acetylcholine receptor α7 subunit (α7nachr), before stimulation (bdl+st36+α-bgt). these mice, together with a group of intestine-specific heme oxygenase-1 (ho-1) knockout (ko) villin-cre-ho-1 mice, were monitored for their body weights before and 14 days after bdl. the levels of plasma cytokines and liver injury-related alanine aminotransferase (alt) and aspartate aminotransferase (ast) were measured by

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Author

Wei Lei; Changcheng Zhao; Jiasen Sun; Yanling Jin; Zhijun Duan

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)