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Can I read Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor on EtoBox?
Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor by Han Li; Yun-hang Gao; Ling Song; Teng-fei Chen; Guang-ping Zhang; Zu-guang Ye; Yue Gao; Wang Huo is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor about?
## Ethnopharmacological relevance: Panax ginseng c. a. meyer (ginseng) is a widely used traditional chinese medicine that has played a beneficial role in the treatment of various diseases, including liver diseases. ginsenoside rg1 is a saponin isolated and purified from ginseng that exerts protective effects on the liver in some liver injury models. 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is a ubiquitous dioxin found mostly in food products that causes liver injury and other human diseases. although significant efforts have been made to reduce the burden of liver disease, there is still a lack of effective treatment methods. ## Aim of the study: Although ginsenoside rg1 was reported to inhibit tcdd-mediated cytochrome p450 1a1 (cyp1a1) induction in hepg2 cells, we sought to verify its hepatoprotective effects and elucidate its mechanism in a tcdd-induced liver injury model in mice. ## Material and methods: The mouse liver injury model was established by intraperitoneal tcdd injection, followed by treatment with various doses of ginsenoside rg1 (50, 100, and 200 mg/kg). clinical indicators of liver injury, such as an increase in serum aspartate aminotransferase and alanine aminot
Who reads Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Han Li; Yun-hang Gao; Ling Song; Teng-fei Chen; Guang-ping Zhang; Zu-guang Ye; Yue Gao; Wang Huo
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)