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Increases in Serum Concentrations of Cardiac Proteins and the Prediction of Early Postoperative Cardiovascular Complications in Noncardiac Surgery Patients by F. Neill; J. W. Sear; G. French; H. Lam; M. Kemp; R. J. L. Hooper; P. Foex is a Medicine article available to read on EtoBox.

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We investigated the use of measurements of serum concentrations of the cardiac proteins troponins I and T as biochemical markers of myocardial cell damage in 80 patients undergoing vascular or major orthopaedic surgery. Holter electrocardiographic monitoring was carried out before surgery and for 3 days after surgery. Blood samples for troponins I and T and creatine kinase‐MB isoenzyme were taken on each of these 4 days. Outcome was assessed at 3 months using a patient questionnaire, general practitioner follow‐up and case notes review. Silent postoperative myocardial ischaemia was detected in 21 patients; increases in troponins I and T and creatine kinase‐MB occurred in four, six and 17 of these patients, respectively. Eight patients suffered major postoperative complications (cardiac death, myocardial ischaemia, congestive cardiac failure, unstable angina and cerebrovascular accident) and 21 minor complications (poorly controlled hypertension needing increased or new additional treatment, palpitations, increased tiredness or shortness of breath in the absence of known respiratory disease). There were no associations between postoperative ischaemia and cardiac protein concentratio

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Author

F. Neill; J. W. Sear; G. French; H. Lam; M. Kemp; R. J. L. Hooper; P. Foex

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0003-2409)

Published

2000

Language

EN

Field

Medicine (Health Sciences)