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Low-dose trimethoprim-sulfamethoxazole treatment for pneumocystis pneumonia in non-human immunodeficiency virus-infected immunocompromised patients: A single-center retrospective observational cohort study by Kei Nakashima; Masahiro Aoshima; Tamao Nakashita; Masahiko Hara; Ayumu Otsuki; Satoshi Noma; Masafumi Misawa; Yoshihito Otsuka; Shinji Motojima is a Medicine article available to read on EtoBox.

What is Low-dose trimethoprim-sulfamethoxazole treatment for pneumocystis pneumonia in non-human immunodeficiency virus-infected immunocompromised patients: A single-center retrospective observational cohort study about?

## Background/purpose: The efficacy of low-dose trimethoprim-sulfamethoxazole (tmp-smx) may be acceptable for the treatment of pneumocystis pneumonia (pcp) in non-human immunodeficiency virus (hiv)-infected patients, with a low incidence of adverse reactions. this study is aimed to evaluate the efficacy and safety of such a regimen for the treatment of non-hiv pcp. ## Methods: We retrospectively enrolled 24 consecutive patients diagnosed with non-hiv pcp who were treated with low-dose tmp-smx (tmp, 4-10 mg/kg/day; smx, 20-50 mg/kg/day). data of the conventional-dose treatment were used as reference. the primary endpoints were the 30- and 180-day survival rates from the day of treatment, and secondary endpoints were the incidence of each adverse reaction and dropout rate from the initial tmp-smx regimen. the survival rate was estimated using the kaplan-meier method with 95% confidence interval (ci). ## Results: The median age of patients was 72 years (54.2% men), and connective tissue disease was the most frequent underlying disease (66.7%) in the low-dose group. the 30- and 180-day survival rates were 95.8% (95% ci: 88.2-100.0%) and 91.0% (95% ci: 79.9%-100.0%), respectively, in th

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Author

Kei Nakashima; Masahiro Aoshima; Tamao Nakashita; Masahiko Hara; Ayumu Otsuki; Satoshi Noma; Masafumi Misawa; Yoshihito Otsuka; Shinji Motojima

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Medicine (Health Sciences)