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Endocannabinoid system: Role in depression, reward and pain control (Review) by Huang, Wen‐Juan; Chen, Wei‐Wei; Zhang, Xia is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Depression and pain co-exist in almost 80% of patients and are associated with impaired health-related quality of life, often contributing to high mortality. However, the majority of patients who suffer from the comorbid depression and pain are not responsive to pharmacological treatments that address either pain or depression, making this comorbidity disorder a heavy burden on patients and society. In ancient times, this depression-pain comorbidity was treated using extracts of the __Cannabis sativa__ plant, known now as marijuana and the mode of action of Δ^9^-tetrahydrocannabinol, the active cannabinoid ingredient of marijuana, has only recently become known, with the identification of cannabinoid receptor type 1 (CB1) and CB2. Subsequent investigations led to the identification of endocannabinoids, anandamide and 2-arachidonoylglycerol, which exert cannabinomimetic effects through the CB1 and CB2 receptors, which are located on presynaptic membranes in the central nervous system and in peripheral tissues, respectively. These endocannabinoids are produced from membrane lipids and are lipohilic molecules that are synthesized on demand and are eliminated rapidly after their usage

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Author

Huang, Wen‐Juan; Chen, Wei‐Wei; Zhang, Xia

Publisher

Spandidos Publications Ltd; Spandidos Publications (ISSN 1791-2997)

Published

2016

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)