Opening book details…
Can I read Perfluorooctane sulfonate alternatives and metabolic syndrome in adults: New evidence from the Isomers of C8 Health Project in China on EtoBox?
Perfluorooctane sulfonate alternatives and metabolic syndrome in adults: New evidence from the Isomers of C8 Health Project in China by Shu Yu; Wen-Ru Feng; Zi-Mian Liang; Xiao-Yun Zeng; Michael S. Bloom; Guo-Cheng Hu; Yang Zhou; Yan-Qiu Ou; Chu Chu; Qing-Qing Li; Yunjiang Yu; Xiao-Wen Zeng; Guang-Hui Dong is a Environmental Science article available to read on EtoBox.
What is Perfluorooctane sulfonate alternatives and metabolic syndrome in adults: New evidence from the Isomers of C8 Health Project in China about?
Chlorinated polyfluoroalkyl ether sulfonates (Cl-PFESAs), are ubiquitous alternatives to perfluorooctane sulfonate (PFOS), a widely used poly- and perfluoroalkyl substance (PFAS). Despite in vivo and in vitro evidence of metabolic toxicity, no study has explored associations of Cl-PFESAs concentrations with metabolic syndrome (MetS) in a human population. To help address this data gap, we quantified 32 PFAS, including 2 PFOS alternative Cl-PFESAs (6:2 and 8:2 Cl-PFESAs) in serum from 1228 adults participating in the cross-sectional Isomers of C8 Health Project in China study. The odds ratios (ORs) and 95% confidence intervals (CIs) of MetS and its various components were estimated using individual PFAS as a continuous or categorical predictor in multivariate regression models. The association between the overall mixture of PFAS and MetS was examined using probit Bayesian Kernel Machine Regression (BKMR-P). Greater serum PFAS concentrations were associated with higher odds of MetS and demonstrated a statistically significant dose-response trend (P for trend < 0.001). For example, each ln-unit (ng/mL) increase in serum 6:2 Cl-PFESA was associated with a higher prevalence of MetS (OR
Who reads Perfluorooctane sulfonate alternatives and metabolic syndrome in adults: New evidence from the Isomers of C8 Health Project in China?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Shu Yu; Wen-Ru Feng; Zi-Mian Liang; Xiao-Yun Zeng; Michael S. Bloom; Guo-Cheng Hu; Yang Zhou; Yan-Qiu Ou; Chu Chu; Qing-Qing Li; Yunjiang Yu; Xiao-Wen Zeng; Guang-Hui Dong
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Environmental Science (Physical Sciences)