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Genomic alterations caused by HPV integration in a cohort of Chinese endocervical adenocarcinomas by Wenhui Li; Wanjun Lei; Xiaopei Chao; Xiaochen Song; Yalan Bi; Huanwen Wu; Ming Wu; Lei Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Genomic alterations caused by HPV integration in a cohort of Chinese endocervical adenocarcinomas about?
## Abstract The association between human papillomavirus (HPV) integration and relevant genomic changes in uterine cervical adenocarcinoma is poorly understood. This study is to depict the genomic mutational landscape in a cohort of 20 patients. HPV+ and HPV− groups were defined as patients with and without HPV integration in the host genome. The genetic changes between these two groups were described and compared by whole-genome sequencing (WGS) and whole-exome sequencing (WES). WGS identified 2916 copy number variations and 743 structural variations. WES identified 6113 somatic mutations, with a mutational burden of 2.4 mutations/Mb. Six genes were predicted as driver genes: PIK3CA, KRAS, TRAPPC12, NDN, GOLGA6L4 and BAIAP3. PIK3CA, NDN, GOLGA6L4, and BAIAP3 were recognized as significantly mutated genes (SMGs). HPV was detected in 95% (19/20) of patients with cervical adenocarcinoma, 7 of whom (36.8%) had HPV integration (HPV+ group). In total, 1036 genes with somatic mutations were confirmed in the HPV+ group, while 289 genes with somatic mutations were confirmed in the group without HPV integration (HPV− group); only 2.1% were shared between the two groups. In the HPV+ group, G
Who reads Genomic alterations caused by HPV integration in a cohort of Chinese endocervical adenocarcinomas?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Wenhui Li; Wanjun Lei; Xiaopei Chao; Xiaochen Song; Yalan Bi; Huanwen Wu; Ming Wu; Lei Li
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)