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Which patients with newly diagnosed prostate cancer need a radionuclide bone scan? An analysis based on 631 patients by Nancy Lee; Rashid Fawaaz; Carl A Olsson; Mitchell C Benson; Daniel P Petrylak; Peter B Schiff; Emilia Bagiella; Arun Singh; Ronald D Ennis is a Medicine article available to read on EtoBox.
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Purpose: Although radionuclide bone scans are frequently recommended as part of the staging evaluation for newly diagnosed prostate cancer, most scans are negative for metastases. We hypothesized that Gleason score, prostate-specific antigen (PSA), and clinical stage could predict for a positive bone scan (BS), and that a low-risk group of patients could be identified in whom BS might be omitted. Methods: All patients who had both pathologic review of their prostate cancer biopsies and radionuclide BS at our institution between 1/90 and 5/96 were studied. Gleason score, PSA, and clinical stage (AJCC, 4th edition) were evaluated by univariate and multivariate analyses for their ability to predict a positive BS. Groups analyzed were Gleason of 2-6 vs. 7 vs. 8 -10; PSA of 0 -15 vs. greater than 15-50 vs. greater than 50; and clinical stage of T1a-T2b vs. T2c-T4. Univariate analysis using 2 and multivariate analysis using logistic regression were performed. ## Results : Of the 631 consecutive patients, 88 (14%) had positive BS. Multivariate analysis (64 excluded due to missing PSA and/or clinical stage) showed Gleason score, PSA, and clinical stage to be significant independent predict
Who reads Which patients with newly diagnosed prostate cancer need a radionuclide bone scan? An analysis based on 631 patients?
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- Author
- Nancy Lee; Rashid Fawaaz; Carl A Olsson; Mitchell C Benson; Daniel P Petrylak; Peter B Schiff; Emilia Bagiella; Arun Singh; Ronald D Ennis
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)