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Acute, Nongenomic Effect of Thyroid Hormones in Preventing Calcium Overload in Newborn Rat Cardiocytes by T. Zinman; V. Shneyvays; N. Tribulova; M. Manoach; A. Shainberg is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract In this study, we examined the acute effects of thyroid hormones (TH) T~3~ and T~4~, leading to improvement of myocardial function through activation of Ca^2+^ extrusion mechanisms and, consequently, prevention of intracellular calcium overload. Extracellular calcium elevation from 1.8 to 3.8 mM caused immediate increase in intracellular calcium level ([Ca^2+^]~i~) in newborn cardiomyocyte cultures. Administration of 10 or 100 nM T~3~ or T~4~ rapidly (within 10 sec) decreased [Ca^2+^]~i~ to its control level. Similar results were obtained when [Ca^2+^]~i~ was elevated by decreasing extracellular Na^+^ concentration, causing backward influx of Ca^2+^ through Na^+^/Ca^2+^ exchanger, or by administration of caffeine, releasing Ca^2+^ from the sarcoplasmic reticulum (SR). Under these conditions, T~3~ or T~4~ decreased [Ca^2+^]~i~. T~3~ and T~4~ also exhibited protective effects during ischemia. T~3~ or T~4~ presence during hypoxia for 120 min in culture medium restricted the increase of [Ca^2+^]~i~ and prevented the pathological effects of its overload. An inhibitor of SR Ca^2+^‐ATPase (SERCA2a), thapsigargin, increases [Ca^2+^]~i~ and in its presence neither T~3~ nor T~4~

Who reads Acute, Nongenomic Effect of Thyroid Hormones in Preventing Calcium Overload in Newborn Rat Cardiocytes?

Author

T. Zinman; V. Shneyvays; N. Tribulova; M. Manoach; A. Shainberg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)